Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial.
Identifieur interne : 001610 ( Main/Exploration ); précédent : 001609; suivant : 001611Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial.
Auteurs : Gerd R. Burmester [Allemagne] ; William F. Rigby [États-Unis] ; Ronald F. Van Vollenhoven [Suède] ; Jonathan Kay [États-Unis] ; Andrea Rubbert-Roth [Allemagne] ; Ricardo Blanco [Espagne] ; Alysha Kadva [États-Unis] ; Sophie Dimonaco [Royaume-Uni]Source :
- Annals of the rheumatic diseases [ 1468-2060 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Anticorps monoclonaux humanisés (usage thérapeutique), Antirhumatismaux (usage thérapeutique), Articulations (imagerie diagnostique), Femelle, Gestion de la pharmacothérapie, Humains, Induction de rémission, Mâle, Méthode en double aveugle, Méthotrexate (usage thérapeutique), Polyarthrite rhumatoïde (imagerie diagnostique), Polyarthrite rhumatoïde (traitement médicamenteux), Radiographie, Résultat thérapeutique, Évolution de la maladie.
- MESH :
- imagerie diagnostique : Articulations, Polyarthrite rhumatoïde.
- traitement médicamenteux : Polyarthrite rhumatoïde.
- usage thérapeutique : Anticorps monoclonaux humanisés, Antirhumatismaux, Méthotrexate.
- Adulte, Adulte d'âge moyen, Femelle, Gestion de la pharmacothérapie, Humains, Induction de rémission, Mâle, Méthode en double aveugle, Radiographie, Résultat thérapeutique, Évolution de la maladie.
English descriptors
- KwdEn :
- Adult, Antibodies, Monoclonal, Humanized (therapeutic use), Antirheumatic Agents (therapeutic use), Arthritis, Rheumatoid (diagnostic imaging), Arthritis, Rheumatoid (drug therapy), Disease Progression, Double-Blind Method, Female, Humans, Joints (diagnostic imaging), Male, Medication Therapy Management, Methotrexate (therapeutic use), Middle Aged, Radiography, Remission Induction, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized, Antirheumatic Agents, Methotrexate.
- diagnostic imaging : Arthritis, Rheumatoid, Joints.
- drug therapy : Arthritis, Rheumatoid.
- Adult, Disease Progression, Double-Blind Method, Female, Humans, Male, Medication Therapy Management, Middle Aged, Radiography, Remission Induction, Treatment Outcome.
Abstract
Investigate whether the efficacy and safety of intravenous tocilizumab (TCZ) demonstrated at week 52 in patients with early rheumatoid arthritis (RA) are maintained to week 104.
DOI: 10.1136/annrheumdis-2016-210561
PubMed: 28389552
Affiliations:
- Allemagne, Espagne, Royaume-Uni, Suède, États-Unis
- Berlin, Californie, Massachusetts, New Hampshire, Svealand
- Berlin, Stockholm
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Le document en format XML
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Burmester</name><affiliation wicri:level="3"><nlm:affiliation>Charité-Universitätsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Charité-Universitätsmedizin Berlin, Free University and Humboldt University of Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Rigby, William F" sort="Rigby, William F" uniqKey="Rigby W" first="William F" last="Rigby">William F. 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type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Rheumatoid (diagnostic imaging)</term><term>Arthritis, Rheumatoid (drug therapy)</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Joints (diagnostic imaging)</term><term>Male</term><term>Medication Therapy Management</term><term>Methotrexate (therapeutic use)</term><term>Middle Aged</term><term>Radiography</term><term>Remission Induction</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term><term>Antirhumatismaux (usage thérapeutique)</term><term>Articulations (imagerie diagnostique)</term><term>Femelle</term><term>Gestion de la pharmacothérapie</term><term>Humains</term><term>Induction de rémission</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Méthotrexate (usage thérapeutique)</term><term>Polyarthrite rhumatoïde (imagerie diagnostique)</term><term>Polyarthrite rhumatoïde (traitement médicamenteux)</term><term>Radiographie</term><term>Résultat thérapeutique</term><term>Évolution de la maladie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term><term>Antirheumatic Agents</term><term>Methotrexate</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Arthritis, Rheumatoid</term><term>Joints</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Articulations</term><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Polyarthrite rhumatoïde</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term><term>Antirhumatismaux</term><term>Méthotrexate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Medication Therapy Management</term><term>Middle Aged</term><term>Radiography</term><term>Remission Induction</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Gestion de la pharmacothérapie</term><term>Humains</term><term>Induction de rémission</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Radiographie</term><term>Résultat thérapeutique</term><term>Évolution de la maladie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Investigate whether the efficacy and safety of intravenous tocilizumab (TCZ) demonstrated at week 52 in patients with early rheumatoid arthritis (RA) are maintained to week 104.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Berlin</li><li>Californie</li><li>Massachusetts</li><li>New Hampshire</li><li>Svealand</li></region><settlement><li>Berlin</li><li>Stockholm</li></settlement></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Burmester, Gerd R" sort="Burmester, Gerd R" uniqKey="Burmester G" first="Gerd R" last="Burmester">Gerd R. Burmester</name></region><name sortKey="Rubbert Roth, Andrea" sort="Rubbert Roth, Andrea" uniqKey="Rubbert Roth A" first="Andrea" last="Rubbert-Roth">Andrea Rubbert-Roth</name></country><country name="États-Unis"><region name="New Hampshire"><name sortKey="Rigby, William F" sort="Rigby, William F" uniqKey="Rigby W" first="William F" last="Rigby">William F. Rigby</name></region><name sortKey="Kadva, Alysha" sort="Kadva, Alysha" uniqKey="Kadva A" first="Alysha" last="Kadva">Alysha Kadva</name><name sortKey="Kay, Jonathan" sort="Kay, Jonathan" uniqKey="Kay J" first="Jonathan" last="Kay">Jonathan Kay</name></country><country name="Suède"><region name="Svealand"><name sortKey="Van Vollenhoven, Ronald F" sort="Van Vollenhoven, Ronald F" uniqKey="Van Vollenhoven R" first="Ronald F" last="Van Vollenhoven">Ronald F. Van Vollenhoven</name></region></country><country name="Espagne"><noRegion><name sortKey="Blanco, Ricardo" sort="Blanco, Ricardo" uniqKey="Blanco R" first="Ricardo" last="Blanco">Ricardo Blanco</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Dimonaco, Sophie" sort="Dimonaco, Sophie" uniqKey="Dimonaco S" first="Sophie" last="Dimonaco">Sophie Dimonaco</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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